Perineurial Basal Cell Carcinoma

Perineurial basal cell carcinoma (PBCC) is a rare subtype of basal cell carcinoma (BCC), which is the most common type of skin cancer.

PBCC is characterized by the involvement of the perineurium, a protective layer of tissue that surrounds the nerves, in the development of the cancer. PBCC typically presents as a slow-growing, painless mass and it is more likely to occur in older individuals. The diagnosis of PBCC is often delayed because it can be mistaken for other types of skin tumors or cysts.

PBCC is usually treated with surgical excision, which involves removing the entire tumor and some surrounding healthy tissue to ensure that all cancer cells are removed. In cases where the tumor is larger or in a difficult location, radiation therapy or Mohs micrographic surgery may be used as an alternative treatment.

In addition, BCCs that are located on the face, may be treated with laser therapy or cryosurgery. In rare cases, PBCC may be treated with topical medications such as imiquimod or 5-fluorouracil. However, it is important to note that these treatment options have not been extensively studied in PBCC, and therefore their efficacy is not well established.